ACROBiosystems – Immune Checkpoint Proteins

General Description

Immune Check Point

Immune checkpoint pathways involve both costimulatory and inhibitory proteins. The costimulatory receptors transduce signals to promote immunity against pathogens. The inhibitory receptors, on the other hand, negatively regulate T-cell activation to prevent excessive inflammation. In recent years, immune checkpoint proteins have attracted increasing attention due to their involvement in cancer development. Often times, tumor cells can hijack the checkpoint pathways to avoid attacks from the immune system. Therefore, many believe that disabling immune checkpoints would help re-engage the body’s immune system to fight against cancers. Intriguingly, anti-CTLA4 and anti-PD1 monoclonal antibodies have already demonstrated anti-tumor effect in patients with a variety of malignancies. Encouraged by this early success, researchers have expanded their investigations into other checkpoint proteins in order to find better ways to treat cancer.To support these efforts, Acrobiosystems has developed an exclusive immune checkpoint protein collection. These products have demonstrated consistent and excellent performance in a variety of assays.

A Comprehensive Collection of Checkpoint Proteins

Acrobiosystems provide a comprehensive collection of immune checkpoint proteins. Acrobiosystems offer Fc-tagged, His-tagged, Strep-tagged, and/or tag free versions of these proteins. In addition to human proteins, Acrobiosystems also offer mouse, rat, rabbit, rhesus macaque, and cynomolgus proteins for your experimental animal studies.

High Quality Materials

The consistency in purity and bioactivity is essential for recombinant proteins. All our proteins have to go through stringent purity and bioactivity assessment in a variety of assays. Common standard include: 
a)Purity greater than 90% by SDS-PAGE and SEC-HPLC 
b)Bioactivity validated in functional ELISA 
c)Endotoxin less than 1EU/µg by the LAL method

PD-1 Purity

Fig .1 The purity of Human PD-L1 (Cat# PD1-H5229) was >95% as determined by SEC-HPLC and >98% as determined by SDS-PAGE.
PD1
Fig .2 Bioactivity of PD1 (Cat# PD1-H5221) was measured in a functional ELISA against human PDL1 (Cat# PD1-H5258).

Biotin-labeled & Heavy-labeled Proteins Available

Biotin labeling can make your assay development much easier. Acrobiosystems offer a variety of ready-to-use biotinylated checkpoint proteins. These proteins are produced using our in-house developed labeling techniques, which confers high bioactivity and minimal batch-to-batch variation.In addition, Acrobiosystems also offer heavy-labeled immune checkpoint proteins, which can be used in quantitative mass spectrometry.

Inhibitor Screening Kit Available

Acrobiosystems are now offering a PD1-PD-L1 inhibitor screening assay kit (Cat# EP-101) for rapid and high throughput screening of candidate inhibitory antibodies or small molecules of the PD1 pathway.

Product List (Please refer to the Complete Product List (EXCEL) for more information)
 

4-1BB  
41B-H8258 Biotinylated Human 4-1BB / TNFRSF9, Fc Tag, ultra sensitivity (primary amine labeling)
41B-H5227 Human 4-1BB / TNFRSF9 Protein
41B-H5258 Human 4-1BB / TNFRSF9 Protein, Fc Tag
41B-M52H7 Mouse 4-1BB / TNFRSF9 Protein
41B-M5258 Mouse 4-1BB /TNFRSF9 Protein, Fc Tag
4-1BB Ligand  
41L-H5257 Human 4-1BB Ligand / TNFSF9 Protein, Fc Tag
41L-M5257 Mouse 4-1BB Ligand / TNFSF9 Protein, Fc Tag
CD80  
CD0-C52H3 Cynomolgus B7-1 / CD80 Protein (HPLC-verified)
B71-H5259 Human B7-1 / CD80 Protein, Fc Tag (HPLC-verified)
B71-H5228 Human B7-1 / CD80 Protein
CD0-M5259 Mouse B7-1 / CD80 Protein, Fc Tag
CD0-C5252 Cynomolgus B7-1 / CD80 Protein, Fc Tag
CD86  
CD6-C52H5 Cynomolgus B7-2 / CD86 Protein (HPLC-verified)
CD6-H5257 Human B7-2 / CD86 Protein, Fc Tag
CD6-H5223 Human B7-2 / CD86 Protein
CD6-M5251 Mouse B7-2 / CD86 Protein, Fc Tag
CD6-M52H0 Mouse B7-2 / CD86 Protein
CD6-C5254 Cynomolgus B7-2 / CD86 Protein, Fc Tag
B7H4  
B74-H5222 Human B7-H4 Protein
B74-H8222 Biotinylated Human B7-H4, ultra sensitivity (primary amine labeling)
BTLA  
BTA-H52E0 Human BTLA Protein
BTA-H5255 Human BTLA (31-134) Protein, Fc Tag
BTA-H5256 Human BTLA (31-150) Protein, Fc Tag
BTA-M52E2 Mouse BTLA Protein
BTA-M5253 Mouse BTLA Protein, Fc Tag
VISTA  
B75-H52H0 Human B7-H5 / Gi24 / VISTA Protein
B75-H82E1 Biotinylated Human B7-H5 / Gi24 / VISTA, Avi Tag (Avitag™)
B75-H5259 Human B7-H5 / Gi24 / VISTA Protein, Fc Tag
CD27  
CD7-H5254 Human CD27 / TNFRSF7 Protein, Fc Tag
CD70  
TN7-H526x Human CD27 Ligand / CD70 Protein, Fc Tag
CD28  
CD8-H5257 Human CD28 Protein, Fc Tag
CD8-M5257 Mouse CD28 Protein, Fc Tag
CD8-M52H6 Mouse CD28 Protein
CD40  
CD0-H5253 Human CD40 / TNFRSF5 Protein, Fc Tag (HPLC-verified)
CD0-H5228 Human CD40 / TNFRSF5 Protein
CD0-C5259 Rhesus macaque CD40 / TNFRSF5 Protein, Fc Tag
CD0-C52H7 Rhesus macaque CD40 / TNFRSF5 Protein
CD0-H82F2 Biotinylated Human CD40 / TNFRSF5, His Tag & Fc Tag, Avi Tag (Avitag™)
TN5-M5259 Mouse CD40 / TNFRSF5 Protein, Fc Tag
TN5-M52H8 Mouse CD40 / TNFRSF5 Protein
CD0-C52H6 Cynomolgus CD40 / TNFRSF5 Protein
CD0-C5257 Cynomolgus CD40 / TNFRSF5 Protein, Fc Tag
CD40 Ligand  
CDL-H5140 Human CD40 Ligand / TNFSF5 Protein
CDL-M5248 Mouse CD40 Ligand / TNFSF5 Protein
CTLA-4  
CT4-H5229 Human CTLA-4 / CD152 Protein
CT4-H9229 Human CTLA-4 / CD152 Protein, C13 and N15-labeled
CT4-H5255 Human CTLA-4 / CD152 Protein, Fc Tag
CT4-C5256 Cynomolgus CTLA-4 Protein, Fc Tag
CT4-C5227 Cynomolgus CTLA-4 Protein
CT4-H5284 Human CTLA-4 / CD152 Protein, Strep Tag
CT4-C82E5 Biotinylated Cynomolgus CTLA-4, Avi Tag (Avitag™)
CT4-H82E4 Biotinylated Human CTLA-4, Avi Tag (Avitag™)
CT4-H82F3 Biotinylated Human CTLA-4, Fc Tag, Avi Tag (Avitag™)
CT4-R5259 Rat CTLA-4 / CD152 Protein, Fc Tag
CT4-R5250 Rabbit CTLA-4 / CD152 Protein, Fc Tag
CT4-H52A4 Human CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin
CT4-M52H5 Mouse CTLA-4 / CD152 Protein
CT4-M5256 Mouse CTLA-4 / CD152 Protein, Fc Tag
DNAM-1  
DN1-H52H6 Human DNAM-1 / CD226 Protein
DN1-H5257 Human DNAM-1 / CD226 Protein, Fc Tag
GITR  
GIR-R5253 Rat GITR / TNFRSF18 Protein, Fc Tag
GIR-H5228 Human GITR / TNFRSF18 Protein
GIR-R5222 Rat GITR / TNFRSF18 Protein
GIR-M5220 Mouse GITR / TNFRSF18 Protein
GIR-M5251 Mouse GITR / TNFRSF18 Protein, Fc Tag
GITR Ligand  
GIL-H526a Human GITR Ligand / TNFSF18 Protein, Fc Tag
HVEM  
HVM-H5258 Human HVEM / TNFRSF14 Protein, Fc Tag
HVM-H5283 Human HVEM / TNFRSF14 Protein, Strep Tag
HVM-H52E9 Human HVEM / TNFRSF14 Protein
HV4-H82F1 Biotinylated Human HVEM / TNFRSF14, Fc Tag, Avi Tag (Avitag™)
ICOS  
ICS-H5250 Human ICOS / CD278 Protein, Fc Tag
LAG-3  
LA3-M52H5 Mouse LAG-3 / CD223 Protein
LA3-H5222 Human LAG-3 / CD223 Protein
LA3-R52H5 Rat LAG3 /CD223 Protein
OX40  
OX0-H5255 Human OX40 / TNFRSF4 / CD134 Protein, Fc Tag
OX0-H5224 Human OX40 / TNFRSF4 / CD134 Protein
OX0-C5220 Rhesus macaque OX40 / TNFRSF4 / CD134 Protein
OX0-C5251 Rhesus macaque OX40 / TNFRSF4 / CD134 Protein, Fc Tag
OX0-M5228 Mouse OX40 / TNFRSF4 / CD134 Protein
OX0-M5259 Mouse OX40 / TNFRSF4 / CD134 Protein, Fc Tag
OX0-H82F7 Biotinylated Human OX40, Fc Tag, Avi Tag (Avitag™)
OX40 Ligand  
OXL-M526x Mouse OX40 Ligand / TNFSF4 Protein, Fc Tag
OXL-H52Q8 Human OX40 Ligand / TNFSF4 Protein (HPLC-verified)
OXL-H526x Human OX40 Ligand / TNFSF4 Protein, Fc Tag
PD-1  
PD1-M8259 Biotinylated Mouse PD-1 / PDCD1, Fc Tag, ultra sensitivity (primary amine labeling)
PD1-H5221 Human PD-1 / PDCD1 Protein (HPLC-verified)
PD1-H5257 Human PD-1 / PDCD1 Protein, Fc Tag (HPLC-verified), low endotoxin
PD1-R52H0 Rabbit PD-1 / PDCD1 Protein
PD1-C5223 Cynomolgus PD-1 / PDCD1 Protein
PD1-C5254 Cynomolgus PD-1 / PDCD1 Protein, Fc Tag
PD1-M5228 Mouse PD-1 / PDCD1 Protein
PD1-HC214 Human PD-1 / PDCD1 Protein, Tag Free, Full Length
PD1-M5259 Mouse PD-1 / PDCD1 Protein, Fc Tag
PD1-M82F4 Biotinylated Mouse PD-1 / PDCD1, Fc Tag, Avi Tag (Avitag™)
PD1-HF257 FITC-Labeled Human PD-1 / PDCD1 Protein, Fc Tag
PD1-H82F2 Biotinylated Human PD-1 / PDCD1, His Tag & Fc Tag, Avi Tag (Avitag™)
PD1-H5284 Human PD-1 / PDCD1 Protein, Strep Tag
PD1-H9221 Human PD-1 / PDCD1 Protein, C13 and N15-labeled
PD1-R52H2 Rat PD-1 / PDCD1 Protein
PD1-RB5251 Rabbit PD-1 / PDCD1 Protein, Fc Tag
PD1-R5253 Rat PD-1 / PDCD1 Protein, Fc Tag
PD1-H82E4 Biotinylated Human PD-1 / PDCD1 (recommended for biopanning), Avi Tag (Avitag™)
PD-L1  
PD1-C52H4 Cynomolgus PD-L1 / B7-H1 Protein
PD1-H5229 Human PD-L1 / B7-H1 Protein (HPLC-verified)
PD1-H5258 Human PD-L1 / B7-H1 Protein, Fc Tag, low endotoxin
PD1-H5282 Human PD-L1 / B7-H1 Protein, Strep Tag
PD1-M52A2 Mouse PD-L1 / B7-H1 Protein, mouse IgG2a Fc Tag, low endotoxin
PD1-H52A3 Human PD-L1 / B7-H1 Protein, mouse IgG1 Fc Tag, low endotoxin (HPLC-verified)
PD1-H9229 Human PD-L1 / B7-H1 Protein, C13 and N15-labeled
PD1-C5253 Cynomolgus PD-L1 / B7-H1 Protein, Fc Tag
PD1-H82F3 Biotinylated Human PD-L1 / B7-H1, His Tag & Fc Tag, Avi Tag (Avitag™)
PD1-M82F5 Biotinylated Mouse PD-L1 / B7-H1, Fc Tag, Avi Tag (Avitag™)
PD1-M5251 Mouse PD-L1 / B7-H1 Protein, Fc Tag
PD1-M5220 Mouse PD-L1 / B7-H1 Protein
PD1-H82E5 Biotinylated Human PD-L1 / B7-H1 (recommended for biopanning), Avi Tag (Avitag™)
PD-L2  
PD2-H5220 Human PD-L2 / B7-DC Protein
PD2-H5251 Human PD-L2 / B7-DC Protein, Fc Tag (HPLC-verified)
PD2-H82E8 Biotinylated Human PD-L2 / B7-DC Protein (recommended for biopanning), Avi Tag (Avitag™)
PD2-M52E3 Mouse PD-L2 / B7-DC Protein
PD2-H82F6 Biotinylated Human PD-L2 / B7-DC, Fc Tag, Avi Tag (Avitag™)
PD2-H52A5 Human PD-L2 / B7-DC Protein, mouse IgG1 Fc Tag
PD2-M5254 Mouse PD-L2 / B7-DC Protein, Fc Tag
SIRP alpha  
SIA-H5251 Human SIRP alpha / CD172a Protein, Fc Tag (HPLC-verified)
SIA-H52A8 Human SIRP alpha / CD172a Protein, mouse IgG1 Fc Tag (HPLC-verified)
SIA-H5351 Human SIRP alpha / CD172a Protein, Fc Tag (HPLC-verified)
SIA-H5225 Human SIRP alpha / CD172a Protein (HPLC-verified)
TIGIT  
TIT-M5257 Mouse TIGIT Protein, Fc Tag
TIT-H52H3 Human TIGIT Protein
TIT-H82F1 Biotinylated Human TIGIT Protein, Fc Tag, Avi Tag (Avitag™)
TIT-H5254 Human TIGIT Protein, Fc Tag
TIT-M52E6 Mouse TIGIT Protein
TIT-C5254 Cynomolgus TIGIT Protein, Fc Tag
TIT-C5223 Cynomolgus TIGIT Protein
TIT-H82E5 Biotinylated Human TIGIT Protein, Avi Tag (Avitag™)
TIM-3  
KI3-H5252 Human TIM-3 / HAVCR2 (22-142) Protein, Fc Tag
TM3-H5229 Human TIM-3 / HAVCR2 Protein
TM3-H5258 Human TIM-3 / HAVCR2 (22-200) Protein, Fc Tag
TI3-H5285 Human TIM-3 / HAVCR2 (22-200) Protein, Strep Tag
TI3-M52H1 Mouse TIM-3 / HAVCR2 Protein
TI3-M5252 Mouse TIM-3 / HAVCR2 Protein, Fc Tag
2B4  
2B4-H5255 Human 2B4 / CD244 / SLAMF4 Protein, Fc Tag
2B4-H5224 Human 2B4 / CD244 / SLAMF4 Protein
B7-H2  
B72-H5221 Human B7-H2 / ICOSLG Protein
CD155  
CD5-H5223 Human CD155 / PVR Protein
CD5-H5251 Human CD155 / PVR Protein, Fc Tag
CD160  
BY5-H5229 Human CD160 Protein
CD47  
CD7-H82F6 Biotinylated Human CD47, Fc Tag, Avi Tag (Avitag™)
CD7-H5256 Human CD47 Protein, Fc Tag (HPLC-verified)
CD7-H5227 Human CD47 Protein
CD7-C5252 Cynomolgus CD47 Protein, Fc Tag
CD7-H52A5 Human CD47 Protein, mouse IgG2a Fc Tag, low endotoxin
CD7-M5251 Mouse CD47 Protein, Fc Tag
B7-H3  
B73-H5253 Human B7-H3 / CD276 Protein, Fc Tag
B73-H52E2 Human B7-H3 / CD276 Protein
B73-M5255 Mouse B7-H3 / CD276 Protein, Fc Tag
Galectin-9  
LG9-H5244 Human Galectin-9 / LGALS9 Protein

 

Please contact us for your any inquiries, questions and information requests.
Tokyo Future Style, Inc.
info@tokyofuturestyle.com
TEL:+81-29-851-9222 FAX:+81-29-851-9220

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